Marcel Kool Selected Research

Rhabdoid Tumor (Rhabdoid Tumors)

1/2022	The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors.
1/2021	Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors.
1/2021	Transposable element insertion as a mechanism of SMARCB1 inactivation in atypical teratoid/rhabdoid tumor.
1/2021	Inhibition of nuclear export restores nuclear localization and residual tumor suppressor function of truncated SMARCB1/INI1 protein in a molecular subset of atypical teratoid/rhabdoid tumors.
11/2019	Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration.
1/2018	Sellar Region Atypical Teratoid/Rhabdoid Tumors (ATRT) in Adults Display DNA Methylation Profiles of the ATRT-MYC Subgroup.
11/2017	Reduced histone H3 K27 trimethylation is encountered in about 50% of atypical teratoid/rhabdoid tumors (AT/RT) but is not associated with molecular subgroup status and outcome.
10/2017	Combined BRD4 and CDK9 inhibition as a new therapeutic approach in malignant rhabdoid tumors.
1/2017	SMAD dependent signaling plays a detrimental role in a fly model of SMARCB1-deficiency and the biology of atypical teratoid/rhabdoid tumors.
3/2015	Analysis of the antiproliferative effects of 3-deazaneoplanocin A in combination with standard anticancer agents in rhabdoid tumor cell lines.

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Marcel Kool Research Topics

Disease

120	Neoplasms (Cancer) 03/2022 - 02/2002
85	Medulloblastoma 03/2022 - 02/2006
19	Brain Neoplasms (Brain Tumor) 11/2021 - 11/2010
17	Ependymoma 01/2022 - 12/2011
13	Glioma (Gliomas) 01/2022 - 12/2011
12	Rhabdoid Tumor (Rhabdoid Tumors) 01/2022 - 06/2013
11	Glioblastoma (Glioblastoma Multiforme) 12/2021 - 01/2012
8	Carcinogenesis 01/2022 - 04/2012
8	Primitive Neuroectodermal Tumors (PNET) 01/2021 - 11/2010
6	Disease Progression 12/2021 - 05/2013
6	Astrocytoma (Pilocytic Astrocytoma) 01/2020 - 08/2013
6	Neoplasm Metastasis (Metastasis) 01/2019 - 04/2012
5	Typical Teratoid Rhabdoid Tumor 01/2022 - 12/2012
4	Chromothripsis 01/2022 - 08/2012
4	Genomic Instability 01/2022 - 06/2016
3	Neuroblastoma 01/2022 - 07/2013
2	Central Nervous System Neoplasms 01/2022 - 01/2022
2	Neuroepithelial Neoplasms (Gliomatosis Cerebri) 01/2020 - 01/2016
2	Isochromosomes 06/2019 - 12/2012
2	Intellectual Disability (Idiocy) 11/2012 - 01/2012
2	Chromosome Aberrations (Chromosome Abnormalities) 04/2011 - 11/2010
1	DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes) 01/2022
1	Li-Fraumeni Syndrome 01/2022
1	Osteosarcoma (Osteogenic Sarcoma) 01/2022
1	Brain Stem Neoplasms (Brain Stem Tumor) 01/2022
1	Chordoma 12/2021
1	Choroid Plexus Papilloma 12/2021
1	Pleomorphic Adenoma 11/2021
1	Residual Neoplasm 01/2021

Drug/Important Bio-Agent (IBA)

29	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2006
19	Messenger RNA (mRNA)IBA 10/2021 - 02/2006
15	Pharmaceutical PreparationsIBA 01/2022 - 02/2002
15	Biological ProductsIBA 01/2021 - 08/2008
14	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 04/2011
14	Biomarkers (Surrogate Marker)IBA 01/2022 - 11/2010
13	RNA (Ribonucleic Acid)IBA 12/2021 - 08/2012
13	MicroRNAs (MicroRNA)IBA 12/2021 - 11/2010
12	ChromatinIBA 01/2021 - 01/2012
9	Histones (Histone)IBA 01/2022 - 01/2012
9	Transcription Factors (Transcription Factor)IBA 12/2021 - 10/2010
6	Phosphotransferases (Kinase)IBA 01/2021 - 01/2010
6	ParaffinIBA 01/2016 - 04/2012
5	NucleotidesIBA 11/2021 - 01/2016
5	Small Interfering RNA (siRNA)IBA 01/2018 - 07/2012
5	Formaldehyde (Formol)FDA Link 01/2016 - 04/2012
4	ProteomeIBA 01/2022 - 10/2018
4	Lysine (L-Lysine)FDA Link 01/2022 - 03/2013
3	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2022 - 12/2011
3	Histone Deacetylase InhibitorsIBA 01/2021 - 12/2012
3	Dactinomycin (Actinomycin)FDA LinkGeneric 12/2020 - 09/2016
3	Temozolomide (Temodar)FDA LinkGeneric 01/2020 - 11/2015
3	CateninsIBA 01/2019 - 11/2010
3	Doxorubicin (Adriamycin)FDA LinkGeneric 11/2017 - 06/2013
3	Telomerase (Telomerase Reverse Transcriptase)IBA 09/2017 - 12/2013
2	Cisplatin (Platino)FDA LinkGeneric 01/2022 - 10/2016
2	Carboplatin (JM8)FDA LinkGeneric 01/2022 - 10/2018
2	Polycomb Repressive Complex 2IBA 01/2022 - 11/2019
2	CarbonIBA 12/2021 - 06/2019
2	Histone Deacetylases (Histone Deacetylase)IBA 01/2021 - 07/2013
2	Arsenic Trioxide (Trisenox)FDA Link 01/2021 - 08/2014
2	Methotrexate (Mexate)FDA LinkGeneric 01/2020 - 11/2017
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2020 - 01/2020
2	Co-Repressor ProteinsIBA 01/2020 - 01/2020
2	HhAntag691IBA 01/2020 - 01/2019
2	Enhancer of Zeste Homolog 2 ProteinIBA 11/2019 - 03/2015
2	Cytostatic AgentsIBA 01/2019 - 10/2016
2	Carrier Proteins (Binding Protein)IBA 01/2017 - 10/2014
2	LigandsIBA 04/2015 - 01/2015
2	Antineoplastic Agents (Antineoplastics)IBA 03/2015 - 07/2014
2	Cytotoxins (Cytolysins)IBA 07/2013 - 12/2011
2	Otx Transcription FactorsIBA 03/2013 - 07/2012
1	abacavir (Ziagen)FDA Link 03/2022
1	Decitabine FDA Link 03/2022
1	Long Noncoding RNAIBA 01/2022
1	sonidegibIBA 01/2022
1	Etoposide (VP 16)FDA LinkGeneric 01/2022
1	Dyneins (Dynein)IBA 01/2022
1	Brachyury protein (Brachyury)IBA 12/2021
1	NivolumabIBA 12/2021
1	IonsIBA 12/2021
1	N-Myc Proto-Oncogene ProteinIBA 10/2021
1	Hypoglycemic Agents (Hypoglycemics)IBA 10/2021
1	Metformin (Glucophage)FDA LinkGeneric 10/2021
1	Tricarboxylic AcidsIBA 10/2021
1	SMARCB1 ProteinIBA 01/2021
1	tyrosyltyrosine (Tyr-Tyr)IBA 01/2021
1	entinostat (MS 275)IBA 01/2021
1	Indicators and Reagents (Reagents)IBA 01/2021
1	selinexorIBA 01/2021

Therapy/Procedure

48	Therapeutics 03/2022 - 11/2010
20	Drug Therapy (Chemotherapy) 01/2022 - 08/2012
10	Radiotherapy 03/2022 - 12/2011
3	Craniospinal Irradiation 01/2020 - 01/2016
3	Immunotherapy 11/2019 - 12/2016
2	Transcutaneous Electric Nerve Stimulation (TENS) 01/2022 - 06/2016
2	Investigational Therapies (Experimental Therapy) 01/2019 - 01/2016
2	Transplantation 01/2019 - 12/2012
1	Combined Modality Therapy 03/2022
1	Aftercare (After-Treatment) 01/2022
1	Heavy Ion Radiotherapy 12/2021